Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disorder caused by polyglutamine repeat expansions in Ataxin-1.Recent evidence supports a role for microRNAs CONTACT REINS (miRNAs) deregulation in SCA1 pathogenesis.However, the extent to which miRNAs may modulate the onset, progression or severity of SCA1 remains lar
Growing evidence supports the effectiveness of deep brain stimulation (DBS) in Set of 4 Mugs treating various psychiatric disorders.DBS has the potential to selectively stimulate specific subcortical brain areas thus providing high-frequency electric stimulation of these regions.The nucleus accumbens (NAc), a frequent DBS target, has shown promise
Background.There is a paradox in Russia and its Arctic regions which reports extremely low rates of occupational diseases (ODs), far below those of other socially and economically advanced circumpolar countries.Yet, there is widespread disregard for occupational health regulations and neglect of basic occupational health services across many indust